SCHEMBL4753326

SCHEMBL4753326

O=C(c1cccc(F)c1)N1CCN(C(c2ccccc2)c2ccccc2)CC1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 5/20 0.80
CYP3A4 P08684 4/20 0.80
CYP2D6 P10635 3/20 0.80
CYP1A2 P05177 3/20 0.80
CYP2C9 P11712 2/20 0.80
TSHR P16473 2/20 0.80
ALDH1A1 P00352 6/20 0.74
MAOB P27338 1/20 0.74
CYP2C19 P33261 1/20 0.68
HIF1A Q16665 1/20 0.68
SMN1; SMN2 Q16637 2/20 0.65
TP53 P04637 2/20 0.64
LMNA P02545 2/20 0.59
NPSR1 Q6W5P4 1/20 0.59
CA12 O43570 1/20 0.56
CA1 P00915 1/20 0.56
CA2 P00918 1/20 0.56
CA7 P43166 1/20 0.56
CA9 Q16790 1/20 0.56
CA14 Q9ULX7 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31350890 1.00 USP2 (0.80) USP2CYP3A4CYP2D6CYP1A2CYP2C9
SCHEMBL5009483 0.93 USP2 (0.70) USP2CYP3A4CYP2D6CYP1A2CYP2C9
SCHEMBL5011593 0.88 TSHR (0.64) USP2CYP3A4CYP2D6CYP1A2CYP2C9
SCHEMBL16598896 0.86 MAOB (0.64) USP2CYP3A4CYP2D6CYP1A2CYP2C9
SCHEMBL31350986 0.85 MAOB (1.00) USP2CYP2D6CYP1A2CYP2C9ALDH1A1
SCHEMBL31350717 0.85 MAOB (0.80) USP2CYP3A4CYP2D6CYP1A2CYP2C9
SCHEMBL20804546 0.84 SMN1; SMN2 (0.90) USP2TSHRALDH1A1SMN1; SMN2LMNA
SCHEMBL16598693 0.84 MAOB (0.74) USP2CYP3A4CYP2D6CYP1A2CYP2C9
SCHEMBL4754213 0.84 MAOB (0.74) USP2CYP3A4CYP2D6CYP1A2CYP2C9
SCHEMBL31351077 0.83 MAOB (0.64) USP2CYP3A4CYP2D6CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008147864-A2 METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS XENON PHARMACEUTICALS INC. (CA) 2008-12-04 WO claimed
WO-2008147864-A2 METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS XENON PHARMACEUTICALS INC. (CA) 2008-12-04 WO disclosed