Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.64 |
| ▸ | EGFR | P00533 | 4/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.64 |
| ▸ | PRKAA1 | Q13131 | 13/20 | 0.61 |
| ▸ | PRKAA2 | P54646 | 11/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.61 |
| ▸ | GRK5 | P34947 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.52 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | INSR | P06213 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16090333 | 0.83 | KDR (0.77) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL2436739 | 0.83 | KDR (0.67) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL2436733 | 0.83 | KDR (0.67) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL4866512 | 0.82 | CDK2 (0.48) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL4888663 | 0.82 | CDK2 (0.48) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL4806038 | 0.81 | KDR (0.71) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL4806046 | 0.81 | KDR (0.71) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL4751145 | 0.81 | KDR (0.73) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL4815396 | 0.81 | KDR (0.69) | KDRPDGFRBEGFRPDGFRAPRKAA1 | |
| SCHEMBL16137754 | 0.80 | KDR (0.75) | KDRPDGFRBEGFRPDGFRAPRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008145398-A1 | 4-ARYLPYRROLE SUBSTITUTED 2-INDOLINE DERIVATIVES ACTIVE AS PROTEIN KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2008-12-04 | — | — | WO | disclosed |