Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609429 | 0.84 | AOC3 (0.54) | TSHRMAPK1AOC3KDM4EL3MBTL1 | |
| SCHEMBL6634361 | 0.83 | TSHR (0.47) | TSHRMAPK1KDM4EGPR88ROCK2 | |
| SCHEMBL8590346 | 0.81 | AOC3 (0.48) | TSHRMAPK1AOC3FFAR1L3MBTL1 | |
| SCHEMBL6975924 | 0.81 | AOC3 (0.48) | TSHRMAPK1AOC3FFAR1L3MBTL1 | |
| SCHEMBL6978184 | 0.81 | AOC3 (0.48) | TSHRMAPK1AOC3FFAR1L3MBTL1 | |
| SCHEMBL3070382 | 0.78 | HIF1A (0.56) | TSHRMAPK1AOC3KDM4EL3MBTL1 | |
| SCHEMBL3909351 | 0.78 | AOC3 (0.43) | TSHRMAPK1AOC3FFAR1KDM4E | |
| SCHEMBL3151292 | 0.77 | KDM4E (0.55) | TSHRFFAR1KDM4EL3MBTL1MEN1 | |
| SCHEMBL27629894 | 0.76 | FFAR1 (0.44) | TSHRMAPK1AOC3FFAR1KDM4E | |
| SCHEMBL27965449 | 0.76 | KDM4E (0.43) | TSHRAOC3FFAR1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151179-A2 | SUBSTITUTED PHENETHYLAMINES | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-12-11 | — | — | WO | disclosed |