Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 13/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4753701 | 0.72 | BDKRB1 (0.65) | BDKRB1 | |
| SCHEMBL4753707 | 0.66 | BDKRB1 (0.47) | BDKRB1MEN1KMT2AHCRTR1HCRTR2 | |
| Trifluoroacetic Acid SCHEMBL4179755 | 0.63 | BDKRB1 (0.62) | BDKRB1 | |
| Trifluoroacetic Acid SCHEMBL4179700 | 0.63 | BDKRB1 (0.62) | BDKRB1 | |
| SCHEMBL4179696 | 0.63 | BDKRB1 (1.00) | BDKRB1 | |
| SCHEMBL4180634 | 0.63 | BDKRB1 (1.00) | BDKRB1 | |
| SCHEMBL4172026 | 0.62 | BDKRB1 (0.71) | BDKRB1 | |
| SCHEMBL4421509 | 0.61 | BDKRB1 (0.48) | BDKRB1ALDH1A1 | |
| SCHEMBL4418718 | 0.61 | BDKRB1 (0.48) | BDKRB1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4172331 | 0.60 | BDKRB1 (0.79) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963285-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007067629-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2007-06-14 | — | — | WO | claimed |
| EP-1963285-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067629-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2007-06-14 | — | — | WO | disclosed |