Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 6/20 | 0.75 |
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.75 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.75 |
| ▸ | HTT | P42858 | 3/20 | 0.73 |
| ▸ | ATM | Q13315 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | CSK | P41240 | 4/20 | 0.68 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.68 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.68 |
| ▸ | ABL1 | P00519 | 2/20 | 0.68 |
| ▸ | RAF1 | P04049 | 2/20 | 0.68 |
| ▸ | LYN | P07948 | 2/20 | 0.68 |
| ▸ | SRC | P12931 | 2/20 | 0.68 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.68 |
| ▸ | ABL2 | P42684 | 2/20 | 0.68 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.68 |
| ▸ | FES | P07332 | 1/20 | 0.68 |
| ▸ | FER | P16591 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789121 | 0.89 | ATM (0.79) | MAP3K7MAP4K2MAPK14HTTATM | |
| SCHEMBL3388452 | 0.88 | MAP3K7 (0.70) | MAP3K7MAP4K2MAPK14HTTATM | |
| SCHEMBL30692261 | 0.85 | MAP3K7 (1.00) | MAP3K7MAP4K2MAPK14CSKEPHA2 | |
| SCHEMBL14690002 | 0.85 | MAP3K7 (1.00) | MAP3K7MAP4K2MAPK14CSKEPHA2 | |
| SCHEMBL3388557 | 0.85 | MAPK14 (0.68) | MAP3K7MAP4K2MAPK14HTTATM | |
| SCHEMBL13708167 | 0.85 | ATM (0.69) | MAP3K7MAP4K2MAPK14HTTATM | |
| SCHEMBL14704592 | 0.85 | MAPK14 (0.78) | MAP3K7MAP4K2MAPK14HTTATM | |
| SCHEMBL4788703 | 0.85 | BRAF (0.89) | MAP3K7MAP4K2MAPK14HTTATM | |
| SCHEMBL4588859 | 0.84 | MAPK14 (0.67) | MAP3K7MAP4K2MAPK14HTTATM | |
| SCHEMBL2285546 | 0.84 | DDR1 (0.71) | MAP3K7MAP4K2MAPK14ATMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |