Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 18/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4754139 | 1.00 | BDKRB1 (0.78) | BDKRB1MEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL4184135 | 0.92 | BDKRB1 (0.77) | BDKRB1MEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL4184132 | 0.92 | BDKRB1 (0.77) | BDKRB1MEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL4162229 | 0.91 | BDKRB1 (0.77) | BDKRB1MEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL4162234 | 0.91 | BDKRB1 (0.77) | BDKRB1MEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL4168680 | 0.91 | BDKRB1 (0.82) | BDKRB1 | |
| SCHEMBL4168675 | 0.91 | BDKRB1 (0.82) | BDKRB1 | |
| SCHEMBL4183928 | 0.88 | BDKRB1 (0.88) | BDKRB1 | |
| SCHEMBL4177061 | 0.88 | BDKRB1 (1.00) | BDKRB1MEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL4180713 | 0.88 | BDKRB1 (0.78) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963285-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007067629-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2007-06-14 | — | — | WO | claimed |
| EP-1963285-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067629-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2007-06-14 | — | — | WO | disclosed |