Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.56 |
| ▸ | PLEKHG3 | A1L390 | 1/20 | 0.56 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.56 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.56 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.56 |
| ▸ | MYO1G | B0I1T2 | 1/20 | 0.56 |
| ▸ | AGPS | O00116 | 1/20 | 0.56 |
| ▸ | MYO1F | O00160 | 1/20 | 0.56 |
| ▸ | SNAP23 | O00161 | 1/20 | 0.56 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.56 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.56 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.56 |
| ▸ | PGRMC1 | O00264 | 1/20 | 0.56 |
| ▸ | CLIC1 | O00299 | 1/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | PDHX | O00330 | 1/20 | 0.56 |
| ▸ | IPO5 | O00410 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699434 | 0.99 | BRAF (0.61) | BRAFPOLBSIGMAR1ESYT2PLEKHG3 | |
| SCHEMBL4696782 | 0.94 | BRAF (0.57) | BRAFSIGMAR1 | |
| SCHEMBL4697958 | 0.94 | BRAF (0.62) | BRAFPOLBESYT2PLEKHG3NBAS | |
| SCHEMBL4696070 | 0.94 | BRAF (0.57) | BRAFSIGMAR1 | |
| SCHEMBL4700683 | 0.91 | BRAF (0.62) | BRAFPOLBESYT2PLEKHG3NBAS | |
| SCHEMBL4699844 | 0.90 | POLB (0.61) | BRAFPOLBESYT2PLEKHG3NBAS | |
| SCHEMBL4697821 | 0.89 | BRAF (0.62) | BRAFINSRLCKLYNHCK | |
| SCHEMBL4697700 | 0.88 | BRAF (0.63) | BRAFPOLBESYT2PLEKHG3NBAS | |
| SCHEMBL4697113 | 0.86 | POLB (0.59) | BRAFPOLBESYT2PLEKHG3NBAS | |
| SCHEMBL4701699 | 0.86 | BRAF (0.70) | BRAFPOLBSIGMAR1ESYT2PLEKHG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275054-A1 | 3-(Substituted Amino)-Pyrazolo[3, 4-D]Pyrimidines as Ephb and Vegfr2 Kinase Inhibitors | HOLZER PHILIPP | 2008-11-06 | — | — | US | claimed |
| EP-1963327-A1 | 3-(SUBSTITUTED AMINO)-PYRAZOLO[3,4-d]PYRIMIDINES AS EPHB AND VEGFR2 KINASE INHIBITORS | Novartis AG (CH) | 2008-09-03 | — | — | EP | claimed |
| WO-2007062805-A1 | 3-(SUBSTITUTED AMINO)-PYRAZOLO[3,4-d]PYRIMIDINES AS EPHB AND VEGFR2 KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-06-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275054-A1 | 3-(Substituted Amino)-Pyrazolo[3, 4-D]Pyrimidines as Ephb and Vegfr2 Kinase Inhibitors | EPHB3, EPHB2, EPHB1 | BRAF 42/4885POLB 1118/4885SIGMAR1 2387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.