Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 4/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA4 | P22748 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.32 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4319319 | 0.73 | PARP1 (0.52) | PARP1HDAC1DPP4NR1H2NR1H3 | |
| SCHEMBL4309187 | 0.71 | PARP1 (0.54) | PARP1HDAC1DPP4NR1H2NR1H3 | |
| SCHEMBL873458 | 0.71 | PARP1 (0.54) | PARP1HDAC1DPP4NR1H2NR1H3 | |
| SCHEMBL873429 | 0.71 | PARP1 (0.54) | PARP1HDAC1DPP4NR1H2NR1H3 | |
| SCHEMBL27933734 | 0.70 | PARP1 (0.55) | PARP1HDAC1DPP4NR1H2NR1H3 | |
| SCHEMBL2086518 | 0.69 | PARP1 (0.50) | PARP1DPP4NR1H2NR1H3CA1 | |
| SCHEMBL873459 | 0.69 | PARP1 (0.54) | PARP1DPP4NR1H2NR1H3CA1 | |
| SCHEMBL30642958 | 0.69 | NR1H2 (0.49) | PARP1HDAC1DPP4NR1H2NR1H3 | |
| SCHEMBL27770701 | 0.69 | PARP1 (0.52) | PARP1HDAC1 | |
| SCHEMBL21551079 | 0.68 | PARP1 (0.48) | PARP1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910362-A1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1910385-A1 | BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019346-A1 | BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |
| WO-2007019345-A1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |