Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13672549 | 0.84 | MAPK14 (0.42) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL4475285 | 0.84 | MAPK14 (0.42) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL13672578 | 0.84 | MAPK14 (0.42) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL4482831 | 0.83 | MAPK14 (0.39) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL13672575 | 0.83 | MAPK14 (0.39) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL13672546 | 0.81 | MAPK14 (0.43) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL4754927 | 0.80 | MAPK14 (0.39) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL4485865 | 0.80 | MAPK14 (0.49) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL4478276 | 0.79 | MAPK14 (0.43) | MAPK14MAPK11MAPK8MAPK9MAPK10 | |
| SCHEMBL4484185 | 0.79 | MAPK14 (0.45) | MAPK14MAPK11MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919914-A2 | P38 MAP KINASE INHIBITORS AND METHODS FOR USING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007023115-A2 | P38 MAP KINASE INHIBITORS AND METHODS FOR USING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-01 | — | — | WO | disclosed |