Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | TYR | P14679 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.58 |
| ▸ | CTSB | P07858 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4754988 | 1.00 | APP (0.77) | APPMAPTTYRKMT2AMEN1 | |
| SCHEMBL3220811 | 0.87 | APP (1.00) | APPMAPTTYRKMT2AMEN1 | |
| SCHEMBL3220795 | 0.87 | APP (1.00) | APPMAPTTYRKMT2AMEN1 | |
| Terrestribisamide SCHEMBL30382198 | 0.85 | TYR (1.00) | APPMAPTTYRKMT2AMEN1 | |
| Terrestribisamide SCHEMBL10735557 | 0.85 | TYR (1.00) | APPMAPTTYRKMT2AMEN1 | |
| Terrestribisamide SCHEMBL31278144 | 0.85 | TYR (1.00) | APPMAPTTYRKMT2AMEN1 | |
| SCHEMBL31297163 | 0.83 | TYR (0.90) | APPMAPTTYRKMT2AMEN1 | |
| SCHEMBL29664123 | 0.83 | TYR (0.90) | APPMAPTTYRKMT2AMEN1 | |
| SCHEMBL4789948 | 0.80 | POLB (0.81) | MAPTKMT2AMEN1POLB | |
| SCHEMBL4789949 | 0.80 | POLB (0.81) | MAPTKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118626-A9 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INST MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008118626-A2 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-10-02 | — | — | WO | disclosed |