Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.63 |
| ▸ | AKT1 | P31749 | 3/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | MTOR | P42345 | 2/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL729992 | 0.86 | PIK3CA (0.72) | PIK3CAAKT1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL4754329 | 0.84 | PIK3CA (0.55) | PIK3CAAKT1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL731971 | 0.84 | PIK3CA (0.63) | PIK3CAAKT1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL730230 | 0.81 | CCNK (0.63) | PIK3CAAKT1PRKCINUDT1 | |
| SCHEMBL732238 | 0.81 | PIK3CA (0.65) | PIK3CAAKT1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL14795050 | 0.81 | PIK3CA (0.51) | PIK3CAAKT1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL14795051 | 0.81 | PIK3CA (0.51) | PIK3CAAKT1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL731887 | 0.80 | PIK3CA (0.60) | PIK3CAAKT1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL742894 | 0.80 | PIK3CA (0.67) | PIK3CAAKT1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL731318 | 0.79 | PIK3CA (0.63) | PIK3CAAKT1PIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144463-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | WO | disclosed |