Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Apomorphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.95 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.95 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.95 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 1.00 |
| ▸ | HPGD | P15428 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 6/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 4/20 | 1.00 |
| ▸ | PKM | P14618 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | G6PD | P11413 | 2/20 | 1.00 |
| ▸ | MPI | P34949 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Apomorphine SCHEMBL21410343 | 1.00 | KDM4E (1.00) | KDM4EHPGDALDH1A1MAPTMAPK1 | |
| Apomorphine SCHEMBL29565637 | 1.00 | KDM4E (1.00) | KDM4EHPGDALDH1A1MAPTMAPK1 | |
| Apomorphine SCHEMBL21846961 | 1.00 | KDM4E (1.00) | KDM4EHPGDALDH1A1MAPTMAPK1 | |
| Apomorphine SCHEMBL30395698 | 1.00 | KDM4E (1.00) | KDM4EHPGDALDH1A1MAPTMAPK1 | |
| Apomorphine SCHEMBL232473 | 1.00 | KDM4E (1.00) | KDM4EHPGDALDH1A1MAPTMAPK1 | |
| Apomorphine SCHEMBL5429071 | 1.00 | KDM4E (1.00) | KDM4EHPGDALDH1A1MAPTMAPK1 | |
| Apomorphine SCHEMBL1321033 | 1.00 | KDM4E (1.00) | KDM4EHPGDALDH1A1MAPTMAPK1 | |
| Apomorphine SCHEMBL5904190 | 0.99 | KDM4E (1.00) | KDM4EHPGDALDH1A1MAPTMAPK1 | |
| Apomorphine SCHEMBL8524 | 0.99 | KDM4E (1.00) | KDM4EHPGDALDH1A1MAPTMAPK1 | |
| (S)Apomorphine SCHEMBL19469972 | 0.99 | KDM4E (1.00) | KDM4EHPGDALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009003147-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | PARKINSON'S INSTITUTE (US) | 2008-12-31 | — | — | WO | disclosed |