Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 19/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3770008 | 0.93 | SSTR5 (0.59) | SSTR5KCNH2HRH1HTR2B | |
| SCHEMBL4756346 | 0.90 | SSTR5 (0.49) | SSTR5HRH1HTR2BNSD2SSTR1 | |
| SCHEMBL3785338 | 0.89 | SSTR5 (0.55) | SSTR5KCNH2HRH1HTR2BNSD2 | |
| SCHEMBL4234199 | 0.88 | SSTR5 (0.54) | SSTR5KCNH2HRH1HTR2B | |
| SCHEMBL3782763 | 0.86 | SSTR5 (0.60) | SSTR5KCNH2HRH1HTR2B | |
| SCHEMBL3777231 | 0.86 | SSTR5 (0.50) | SSTR5KCNH2HRH1HTR2B | |
| SCHEMBL3770113 | 0.85 | SSTR5 (0.51) | SSTR5KCNH2HRH1HTR2B | |
| SCHEMBL3773095 | 0.85 | SSTR5 (0.51) | SSTR5KCNH2HRH1HTR2B | |
| SCHEMBL3767663 | 0.84 | SSTR5 (0.53) | SSTR5KCNH2HRH1HTR2BSSTR1 | |
| SCHEMBL3781057 | 0.83 | SSTR5 (0.48) | SSTR5KCNH2HRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007110340-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-04 | — | — | WO | disclosed |