Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 7/20 | 0.43 |
| ▸ | AURKA | O14965 | 5/20 | 0.43 |
| ▸ | VSIR | Q9H7M9 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.37 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13985468 | 0.77 | AURKA (0.41) | DGAT1AURKAHDAC1TRPC5TNKS | |
| SCHEMBL4789994 | 0.74 | AURKA (0.43) | AURKATRPC5TNKSTNKS2ADORA2B | |
| SCHEMBL4789991 | 0.73 | AURKA (0.47) | AURKATRPC5ADORA2B | |
| SCHEMBL209704 | 0.69 | AURKA (0.53) | AURKAHDAC4HDAC1PARP1 | |
| SCHEMBL208759 | 0.69 | CHEK2 (0.40) | DGAT1AURKAVSIRTNKSTNKS2 | |
| SCHEMBL208728 | 0.68 | AURKA (0.47) | AURKATRPC5TNKSTNKS2ADORA2B | |
| SCHEMBL210610 | 0.68 | MEN1 (0.43) | DGAT1AURKATNKSTNKS2 | |
| SCHEMBL211374 | 0.67 | AURKA (0.45) | DGAT1AURKATRPC5KRASADORA2B | |
| SCHEMBL4757469 | 0.67 | AURKA (0.47) | AURKAHDAC4HDAC1 | |
| SCHEMBL4790505 | 0.67 | AURKA (0.54) | AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | disclosed |