Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | CA1 | P00915 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.52 |
| ▸ | STS | P08842 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2088837 | 0.85 | MAPT (0.79) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL6835771 | 0.85 | MAPT (0.79) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL1951546 | 0.84 | MAPT (1.00) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL7402196 | 0.84 | MAPT (0.77) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL10295156 | 0.82 | MAPT (0.75) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL2469151 | 0.82 | MAPT (0.89) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL204175 | 0.82 | MAPT (0.75) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL1794811 | 0.82 | MAPT (0.74) | MAPTRAB9ACA1CA2NPC1 | |
| SCHEMBL943071 | 0.81 | CA12 (0.59) | MAPTCA1CA2MEN1KMT2A | |
| SCHEMBL27507057 | 0.81 | MAPT (0.68) | MAPTRAB9ACA1CA2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1882684-A1 | PYRROLIDINE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2008-01-30 | — | — | EP | disclosed |
| CN-100348569-C | Induction of apoptosis in cancer cells | BURNHAM INST (US) | 2007-11-14 | — | — | CN | disclosed |
| CN-1659130-A | Induction of apoptosis in cancer cells | BURNHAM INST (US) | 2005-08-24 | — | — | CN | disclosed |