Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 6/20 | 0.40 |
| ▸ | KIF5B | P33176 | 6/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | ETV6 | P41212 | 5/20 | 0.40 |
| ▸ | CCDC6 | Q16204 | 4/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178858 | 0.88 | FYN (0.57) | FYNMEN1KMT2ANPC1CASP3 | |
| SCHEMBL4179850 | 0.86 | FYN (0.71) | FYNMEN1KMT2ANPC1CASP3 | |
| SCHEMBL13905642 | 0.86 | FYN (0.52) | FYNMEN1KMT2ANPC1CASP3 | |
| SCHEMBL4178628 | 0.82 | KMT2A (0.69) | FYNMEN1KMT2ANPC1CASP3 | |
| SCHEMBL4168402 | 0.82 | KMT2A (0.58) | FYNMEN1KMT2ANPC1CASP3 | |
| SCHEMBL4171309 | 0.81 | LCK (0.50) | FYNMEN1KMT2ANPC1CASP3 | |
| SCHEMBL4163338 | 0.81 | LCK (0.50) | FYNMEN1KMT2ANPC1CASP3 | |
| SCHEMBL4173163 | 0.80 | FYN (0.47) | FYNMEN1KMT2ANPC1CASP3 | |
| SCHEMBL4174571 | 0.80 | FYN (0.47) | FYNMEN1KMT2ANPC1CASP3 | |
| SCHEMBL4180644 | 0.80 | NPC1 (0.47) | FYNMEN1KMT2ANPC1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993552-A2 | USE OF PYRAZOLO[1,5A]PYRIMIDIN-7-YL AMINE DERIVATIVES IN THE TREATMENT OF NEUROLOGICAL DISORDERS | Novartis AG (CH) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007103432-A9 | USE OF PYRAZOLO[1,5A]PYRIMIDIN-7-YL AMINE DERIVATIVES IN THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2008-01-10 | — | — | WO | disclosed |
| WO-2007103432-A2 | USE OF PYRAZOLO[1,5A]PYRIMIDIN-7-YL AMINE DERIVATIVES IN THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2007-09-13 | — | — | WO | disclosed |