Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 15/20 | 0.59 |
| ▸ | EGLN2 | Q96KS0 | 14/20 | 0.49 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | ASPH | Q12797 | 1/20 | 0.46 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL522413 | 0.94 | EGLN1 (0.67) | EGLN1EGLN2BBOX1THRATHRB | |
| SCHEMBL5072578 | 0.88 | EGLN1 (0.67) | EGLN1EGLN2BBOX1THRATHRB | |
| SCHEMBL523234 | 0.87 | EGLN1 (0.77) | EGLN1EGLN2THRATHRB | |
| SCHEMBL523081 | 0.86 | EGLN1 (0.77) | EGLN1EGLN2BBOX1THRATHRB | |
| SCHEMBL4757894 | 0.84 | EGLN1 (0.70) | EGLN1EGLN2BBOX1THRATHRB | |
| SCHEMBL522016 | 0.82 | EGLN1 (0.74) | EGLN1EGLN2BBOX1THRATHRB | |
| SCHEMBL523678 | 0.80 | EGLN1 (0.58) | EGLN1EGLN2THRATHRB | |
| SCHEMBL4757892 | 0.79 | EGLN1 (0.61) | EGLN1EGLN2BBOX1THRATHRB | |
| SCHEMBL5070912 | 0.78 | EGLN1 (0.68) | EGLN1EGLN2BBOX1THRATHRB | |
| SCHEMBL523426 | 0.77 | GFER (0.46) | EGLN1EGLN2LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009002533-A1 | INFLAMMATORY BOWEL DISEASE THERAPIES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2008-12-31 | — | — | WO | disclosed |