Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 11/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211566 | 0.90 | AURKA (0.66) | AURKACYP3A4CYP2D6CYP2C9AURKB | |
| SCHEMBL14495789 | 0.89 | AURKA (0.65) | AURKACYP3A4CYP2D6CYP2C9AURKB | |
| SCHEMBL208518 | 0.87 | AURKA (0.80) | AURKACYP3A4CYP2D6CYP2C9AURKB | |
| SCHEMBL209571 | 0.86 | AURKA (0.80) | AURKACYP3A4CYP2D6CYP2C9AURKB | |
| SCHEMBL210791 | 0.86 | AURKA (0.80) | AURKACYP3A4CYP2D6CYP2C9AURKB | |
| SCHEMBL209764 | 0.86 | AURKA (0.62) | AURKACYP3A4CYP2D6CYP2C9AURKB | |
| SCHEMBL208782 | 0.86 | AURKA (0.67) | AURKACYP3A4CYP2D6CYP2C9AURKB | |
| SCHEMBL210962 | 0.84 | FGFR1 (0.68) | AURKACYP3A4CYP2D6CYP2C9AURKB | |
| SCHEMBL208651 | 0.84 | FGFR1 (0.70) | AURKACYP3A4CYP2D6CYP2C9AURKB | |
| SCHEMBL209744 | 0.83 | AURKA (0.59) | AURKACYP3A4CYP2D6CYP2C9AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | disclosed |