Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 14/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL210621 | 0.85 | AURKA (0.69) | AURKAIKBKETBK1CDK2 | |
| SCHEMBL209434 | 0.83 | AURKA (0.58) | AURKA | |
| SCHEMBL211237 | 0.82 | AURKA (0.58) | AURKAFLT3KCNH2 | |
| SCHEMBL208448 | 0.81 | AURKA (0.74) | AURKAIKBKETBK1CDK2 | |
| SCHEMBL13985671 | 0.80 | AURKA (0.48) | AURKAFLT3KCNH2 | |
| SCHEMBL13985585 | 0.80 | AURKA (0.42) | AURKAFLT3KCNH2 | |
| SCHEMBL4757493 | 0.79 | AURKA (0.54) | AURKAFLT3KCNH2 | |
| SCHEMBL13985465 | 0.79 | AURKA (0.51) | AURKAFLT3KCNH2 | |
| SCHEMBL13985733 | 0.79 | AURKA (0.77) | AURKAFLT3KCNH2 | |
| SCHEMBL211070 | 0.79 | AURKA (0.56) | AURKAFLT3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | disclosed |