Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL665930 | 0.84 | BRAF (0.55) | PDE4BPDE4APDE4CPDE4DPIK3CD | |
| SCHEMBL666409 | 0.78 | BRAF (0.55) | PDE4BPDE4APDE4CPDE4DPIK3CD | |
| SCHEMBL4374447 | 0.75 | BRAF (0.48) | CHEK2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4380906 | 0.75 | RAF1 (0.48) | CHEK2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4380695 | 0.74 | BRAF (0.47) | CHEK2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL662774 | 0.72 | KDR (0.57) | PDE4BPDE4APDE4CPDE4DCHEK2 | |
| SCHEMBL4375565 | 0.71 | FGFR2 (0.45) | MEN1KMT2A | |
| SCHEMBL666851 | 0.71 | KDR (0.52) | CHEK2BRAF | |
| SCHEMBL5017339 | 0.70 | CHEK2 (0.44) | PDE4BPDE4APDE4CPDE4DCHEK2 | |
| SCHEMBL6364911 | 0.69 | EGFR (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058342-A1 | Quinazoline Derivatives As Angiogenesis Inhibitors | ASTRAZENECA AB (SE) | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058342-A1 | Quinazoline Derivatives As Angiogenesis Inhibitors | VEGFA, KDR, FLT1 | PDE4B 3267/4885PDE4A 3014/4885PDE4C 3199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.