Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.35 |
| ▸ | RELA | Q04206 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14259285 | 0.92 | EPHX2 (0.47) | EPHX2ATMKDM1AMAOBIDO1 | |
| SCHEMBL5034414 | 0.92 | EPHX2 (0.47) | EPHX2ATMKDM1AMAOBIDO1 | |
| SCHEMBL7423742 | 0.91 | EPHX2 (0.48) | EPHX2ATMKDM1AMAOBIDO1 | |
| SCHEMBL4654164 | 0.91 | EPHX2 (0.48) | EPHX2ATMKDM1AMAOBIDO1 | |
| SCHEMBL14016078 | 0.91 | EPHX2 (0.48) | EPHX2ATMKDM1AMAOBIDO1 | |
| SCHEMBL4705777 | 0.84 | ATM (0.39) | ATMKMT2AMEN1GHSRKCNH2 | |
| SCHEMBL4705783 | 0.84 | ATM (0.39) | ATMKMT2AMEN1GHSRKCNH2 | |
| SCHEMBL14015839 | 0.80 | EPHX2 (0.47) | EPHX2ATMKDM1AMAOBIDO1 | |
| SCHEMBL4914877 | 0.80 | EPHX2 (0.47) | EPHX2ATMKDM1AMAOBIDO1 | |
| SCHEMBL14348198 | 0.77 | EPHX2 (0.49) | EPHX2ATMKDM1AMAOBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658069-B1 | HETEROCYCLIC AMIDE DERIVATIVES WHICH POSSESS GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | disclosed |