Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 4/20 | 0.63 |
| ▸ | PIM1 | P11309 | 3/20 | 0.63 |
| ▸ | GSK3B | P49841 | 2/20 | 0.63 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.63 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.63 |
| ▸ | CLK1 | P49759 | 1/20 | 0.63 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.63 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL383428 | 0.87 | PIM1 (0.60) | CDC7PIM1GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL383364 | 0.87 | PIM1 (0.62) | CDC7PIM1GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL3328360 | 0.86 | PIM1 (0.61) | CDC7PIM1GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL385759 | 0.86 | PIM1 (0.61) | CDC7PIM1GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL3330958 | 0.86 | CDC7 (0.61) | CDC7PIM1GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL3331227 | 0.86 | PIM1 (0.58) | CDC7PIM1GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL385521 | 0.85 | PIM1 (0.60) | CDC7PIM1GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL3329151 | 0.85 | CDC7 (0.59) | CDC7PIM1GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL383423 | 0.85 | PIM1 (0.59) | CDC7PIM1GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL12514652 | 0.84 | PIM1 (0.58) | CDC7PIM1GSK3BCSNK2A1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948617-A2 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | Exelixis, Inc. (US) | 2008-07-30 | — | — | EP | claimed |
| WO-2007048065-A2 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS, INC. (US) | 2007-04-26 | — | — | WO | claimed |