SCHEMBL4759742

SCHEMBL4759742

CCCCCCCC(CCCCNS(=O)(=O)c1cccs1)CN1C(=O)c2ccccc2C1=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
TSHR P16473 3/20 0.43
ALDH1A1 P00352 3/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
KDM4E B2RXH2 2/20 0.43
MAPT P10636 1/20 0.43
BRD4 O60885 2/20 0.42
HTT P42858 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
ATM Q13315 1/20 0.40
NPY5R Q15761 1/20 0.40
USP2 O75604 1/20 0.39
HSD17B10 Q99714 1/20 0.39
PKM P14618 1/20 0.39
RECQL P46063 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27601021 0.81 CYP2D6 (0.54) CYP2D6CYP2C9CYP2C19TSHRALDH1A1
SCHEMBL27601052 0.80 CYP2D6 (0.70) CYP2D6CYP2C9CYP2C19TSHRALDH1A1
SCHEMBL18256567 0.79 CES1 (0.48) CYP2C19ALDH1A1MEN1KMT2A
SCHEMBL26722458 0.79 CES1 (0.48) CYP2C19ALDH1A1MEN1KMT2A
SCHEMBL18248457 0.79 CES1 (0.48) CYP2C19ALDH1A1MEN1KMT2A
SCHEMBL23052533 0.79 CYP2D6 (0.72) CYP2D6CYP2C9CYP2C19TSHRALDH1A1
SCHEMBL16307244 0.79 CES1 (0.48) CYP2C19ALDH1A1MEN1KMT2A
SCHEMBL27583579 0.78 CYP2D6 (0.61) CYP2D6CYP2C9CYP2C19TSHRALDH1A1
SCHEMBL27583581 0.78 CYP2D6 (0.61) CYP2D6CYP2C9CYP2C19TSHRALDH1A1
SCHEMBL27619625 0.77 TSHR (0.46) CYP2D6CYP2C9CYP2C19TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1986637-A1 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS Laboratoires Serono SA (CH) 2008-11-05 EP disclosed
WO-2007093557-A1 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS LABORATOIRES SERONO S.A. (CH) 2007-08-23 WO disclosed
EP-1470102-A1 SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) Applied Research Systems ARS Holding N.V. (AN) 2004-10-27 EP disclosed
WO-2003064376-A1 SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2003-08-07 WO disclosed