Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.60 |
| ▸ | ERBB3 | P21860 | 4/20 | 0.60 |
| ▸ | MPL | P40238 | 2/20 | 0.52 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.48 |
| ▸ | PIP4K2B | P78356 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4109552 | 0.88 | MPL (0.52) | EGFRERBB3MPLPIP4K2APIP4K2B | |
| SCHEMBL2175670 | 0.84 | EGFR (0.68) | EGFRERBB3MPLJAK3MEN1 | |
| SCHEMBL2173971 | 0.84 | EGFR (0.72) | EGFRERBB3JAK3MEN1NPC1 | |
| SCHEMBL2177484 | 0.79 | EGFR (0.57) | EGFRERBB3ABL1BCRMEN1 | |
| SCHEMBL2173891 | 0.76 | EGFR (0.60) | EGFRERBB3MPLMEN1KMT2A | |
| SCHEMBL4760021 | 0.75 | EGFR (0.51) | EGFRERBB3MPLAURKBIRAK4 | |
| SCHEMBL5735264 | 0.75 | CYP1A2 (0.58) | EGFRERBB3PIP4K2APIP4K2BAURKA | |
| SCHEMBL2174917 | 0.75 | EGFR (0.64) | EGFRERBB3MEN1NPC1RAB9A | |
| SCHEMBL6499835 | 0.73 | EGFR (0.65) | EGFRERBB3MEN1NPC1RAB9A | |
| SCHEMBL2175771 | 0.73 | EGFR (0.54) | EGFRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1901747-A2 | PYRIMIDINE-BASED CDK INHIBITORS FOR TREATING PAIN | Ingenium Pharmaceuticals AG (DE) | 2008-03-26 | — | — | EP | claimed |
| WO-2006125616-A2 | PYRIMIDINE-BASED CDK INHIBITORS FOR TREATING PAIN | INGENIUM PHARMACEUTICALS AG (DE) | 2006-11-30 | — | — | WO | claimed |
| EP-1678147-A1 | PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES | GPC Biotech AG (DE) | 2006-07-12 | — | — | EP | claimed |
| WO-2005026129-A1 | PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES | GPC BIOTECH AG (DE) | 2005-03-24 | — | — | WO | claimed |