Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3549991 | 0.86 | HDAC1 (0.53) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL3555346 | 0.83 | HDAC1 (0.55) | HDAC1HDAC2ADORA2A | |
| SCHEMBL3554552 | 0.82 | HDAC1 (0.56) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL8420480 | 0.82 | HDAC1 (0.56) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL3554525 | 0.82 | HDAC2 (0.58) | HDAC1HDAC3HDAC2ADORA2A | |
| SCHEMBL16083176 | 0.81 | HDAC1 (0.55) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL3552621 | 0.81 | HDAC1 (0.59) | HDAC1HDAC2ADORA2A | |
| SCHEMBL4718319 | 0.81 | HDAC1 (0.64) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL3557105 | 0.81 | HDAC1 (0.55) | HDAC1HDAC3HDAC2ADORA2A | |
| SCHEMBL3554480 | 0.80 | HDAC1 (0.60) | HDAC1HDAC2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904452-A2 | HISTONE DEACETYLASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-04-02 | — | — | EP | claimed |
| WO-2007011626-A2 | HISTONE DEACETYLASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2007-01-25 | — | — | WO | claimed |