Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 3/20 | 0.41 |
| ▸ | SI | P14410 | 3/20 | 0.41 |
| ▸ | GLB1 | P16278 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 5/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14260876 | 1.00 | MGAM (0.41) | MGAMSIGLB1HTR1ACHRM2 | |
| SCHEMBL14367251 | 1.00 | MGAM (0.41) | MGAMSIGLB1HTR1ACHRM2 | |
| SCHEMBL6232907 | 1.00 | MGAM (0.41) | MGAMSIGLB1HTR1ACHRM2 | |
| SCHEMBL3340637 | 1.00 | MGAM (0.41) | MGAMSIGLB1HTR1ACHRM2 | |
| SCHEMBL14394993 | 1.00 | MGAM (0.41) | MGAMSIGLB1HTR1ACHRM2 | |
| SCHEMBL20833339 | 0.80 | MGAM (0.37) | MGAMSIGLB1HTR1ACHRM2 | |
| SCHEMBL22260013 | 0.78 | MGAM (0.37) | MGAMSIGLB1HTR1ACHRM2 | |
| SCHEMBL25972411 | 0.77 | MGAM (0.37) | MGAMSIGLB1HTR1ACHRM2 | |
| SCHEMBL25972414 | 0.77 | MGAM (0.39) | MGAMSIGLB1HTR1ACHRM2 | |
| SCHEMBL22260012 | 0.75 | MGAM (0.38) | MGAMSIGLB1HTR1ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996202-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007104933-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |