SCHEMBL4760417

SCHEMBL4760417

COc1ccccc1N(F)N(F)F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.50
CA2 P00918 3/20 0.50
CA7 P43166 2/20 0.50
CA9 Q16790 2/20 0.50
CA12 O43570 1/20 0.50
CA4 P22748 1/20 0.50
CA14 Q9ULX7 1/20 0.50
ALDH1A1 P00352 3/20 0.41
TDP1 Q9NUW8 3/20 0.41
TP53 P04637 1/20 0.41
TSHR P16473 1/20 0.41
ADRA2B P18089 1/20 0.41
PTGS1 P23219 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
MAPK1 P28482 1/20 0.40
HTT P42858 1/20 0.40
ENPP2 Q13822 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
ESR1 P03372 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4302129 0.82 CA1 (0.55) CA1CA2CA7CA9CA12
SCHEMBL4540956 0.81 CA1 (0.60) CA1CA2CA7CA9CA12
Hydrochloric Acid SCHEMBL28200109 0.77 CA1 (0.48) CA1CA2CA7CA9CA12
SCHEMBL2539698 0.75 CA1 (0.57) CA1CA2CA7CA9CA12
SCHEMBL17485907 0.75 CA1 (0.57) CA1CA2CA7CA9CA12
SCHEMBL29449742 0.74 CA1 (0.50) CA1CA2CA7CA9CA12
SCHEMBL4669496 0.74 CA1 (0.50) CA1CA2CA7CA9CA12
SCHEMBL20386672 0.74 CA1 (0.50) CA1CA2CA7CA9CA12
SCHEMBL14317695 0.73 CA1 (0.55) CA1CA2CA7CA9CA12
Hydrochloric Acid SCHEMBL2862732 0.73 CA1 (0.55) CA1CA2CA7CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1957109-A2 MODULATORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF Sirtris Pharmaceuticals, Inc. (US) 2008-08-20 EP disclosed
EP-1898897-A2 METHODS AND RELATED COMPOSITIONS FOR TREATING OR PREVENTING OBESITY, INSULIN RESISTANCE DISORDERS, AND MITOCHONDRIAL-ASSOCIATED DISORDERS Sirtris Pharmaceuticals, Inc. (US) 2008-03-19 EP disclosed
WO-2007102861-A2 MODULATORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF SIRTRIS PHARMACEUTICALS, INC. (US) 2007-09-13 WO disclosed
WO-2007008548-A2 METHODS AND RELATED COMPOSITIONS FOR TREATING OR PREVENTING OBESITY, INSULIN RESISTANCE DISORDERS, AND MITOCHONDRIAL-ASSOCIATED DISORDERS SIRTRIS PHARMACEUTICALS, INC. (US) 2007-01-18 WO disclosed
EP-1247093-A2 SCREENING ASSAYS USING INTRAMITOCHONDRIAL CALCIUM MITOKOR (US) 2002-10-09 EP disclosed
WO-2001051923-A2 SCREENING ASSAYS USING INTRAMITOCHONDRIAL CALCIUM MITOKOR (US) 2001-07-19 WO disclosed