Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 2/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL273348 | 0.83 | KDM4E (0.51) | KDM4EMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL273592 | 0.82 | IDO1 (0.53) | KDM4EMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL273038 | 0.79 | NR1H4 (0.58) | KDM4EMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL278699 | 0.79 | NR1H4 (0.58) | KDM4EMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL274161 | 0.77 | NR1H4 (0.59) | KDM4EMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL273620 | 0.73 | AURKA (0.45) | KDM4EMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL5731809 | 0.68 | MAPKAPK2 (0.40) | KDM4EMEN1KMT2AHPGDCYP2C19 | |
| SCHEMBL273149 | 0.65 | GAA (0.56) | KDM4EMEN1KMT2AHPGDHTR2A | |
| SCHEMBL273902 | 0.65 | MAPK1 (0.57) | KDM4EMEN1KMT2AHPGDHTT | |
| SCHEMBL27594856 | 0.65 | MEN1 (0.59) | KDM4EMEN1KMT2AHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963331-A1 | AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007070796-A1 | AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |