Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 20/20 | 0.60 |
| ▸ | ERBB3 | P21860 | 17/20 | 0.60 |
| ▸ | ERBB4 | Q15303 | 17/20 | 0.60 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | CSK | P41240 | 1/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3505007 | 0.99 | EGFR (0.59) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL2747638 | 0.93 | EGFR (0.69) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL3505976 | 0.92 | EGFR (0.71) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| Hydrochloric Acid SCHEMBL3505212 | 0.90 | EGFR (0.72) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| Hydrochloric Acid SCHEMBL3507384 | 0.88 | EGFR (0.56) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL2749210 | 0.88 | EGFR (0.69) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| Hydrochloric Acid SCHEMBL2747915 | 0.87 | EGFR (0.68) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL4722431 | 0.86 | EGFR (0.54) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL3506927 | 0.85 | EGFR (0.55) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL13226139 | 0.85 | EGFR (0.69) | EGFRERBB2ERBB3ERBB4BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957495-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007064045-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-06-07 | — | — | WO | disclosed |