Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 3/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4760875 | 0.94 | MAPK13 (0.49) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL4245202 | 0.94 | MAPK13 (0.53) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL4240989 | 0.90 | MAPK13 (0.50) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL4240297 | 0.90 | MAPK13 (0.50) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL4246281 | 0.88 | MAPK13 (0.43) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL4237635 | 0.86 | MAPK13 (0.48) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL4241190 | 0.84 | MAPK11 (0.49) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL4246284 | 0.83 | MAPK13 (0.44) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL4246294 | 0.83 | MAPK11 (0.55) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL4236860 | 0.82 | MAPK11 (0.40) | MAPK13MAPK11CYP2C9MAPK12MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919919-A1 | PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN | Astellas Pharma Inc. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026950-A1 | PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |