SCHEMBL4761463

SCHEMBL4761463

Cc1c(N2CC(F)C(C(N)CNC(N)=O)C2)c(F)cc2c(=O)n(N)c(=O)n(C3CC3)c12

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 10/20 0.38
SCN5A Q14524 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1385263 0.92 KCNH2 (0.38) KCNH2SCN5A
SCHEMBL1385257 0.92 KCNH2 (0.38) KCNH2SCN5A
SCHEMBL4525447 0.92 KCNH2 (0.38) KCNH2SCN5A
SCHEMBL4525466 0.92 KCNH2 (0.38) KCNH2SCN5A
SCHEMBL4525456 0.92 KCNH2 (0.38) KCNH2SCN5A
SCHEMBL1385252 0.92 KCNH2 (0.38) KCNH2SCN5A
SCHEMBL4506792 0.86 KCNH2 (0.49) KCNH2SCN5A
SCHEMBL4506797 0.86 KCNH2 (0.49) KCNH2SCN5A
SCHEMBL4506784 0.86 KCNH2 (0.49) KCNH2SCN5A
SCHEMBL4759531 0.85

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1255739-B1 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS WARNER LAMBERT CO (US) 2008-06-11 EP claimed