Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.55 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | INSR | P06213 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | PLK1 | P53350 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4761170 | 0.93 | EGFR (0.49) | EGFRGAKERBB2ERBB4ABL1 | |
| SCHEMBL4761509 | 0.91 | EGFR (0.48) | EGFRGAKERBB2ERBB4ABL1 | |
| SCHEMBL4761860 | 0.89 | EGFR (0.58) | EGFRGAKERBB2ERBB4ERBB3 | |
| SCHEMBL4763230 | 0.89 | EGFR (0.62) | EGFRGAKERBB2ERBB4ERBB3 | |
| SCHEMBL4760093 | 0.83 | EGFR (0.52) | EGFRERBB2ERBB4ERBB3ABL1 | |
| SCHEMBL4762253 | 0.83 | EGFR (0.47) | EGFRGAKERBB2ERBB4ABL1 | |
| SCHEMBL28407550 | 0.81 | EGFR (0.80) | EGFRGAKERBB2ERBB4ERBB3 | |
| SCHEMBL4009043 | 0.81 | EGFR (0.63) | EGFRGAKERBB2ERBB4ERBB3 | |
| SCHEMBL4762431 | 0.80 | EGFR (0.47) | EGFRGAKERBB2ERBB4ABL1 | |
| Hydrochloric Acid SCHEMBL4000093 | 0.80 | EGFR (0.62) | EGFRGAKERBB2ERBB4ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1454907-B1 | Quninazoline and pyridopyrimidine derivatives | GLAXO GROUP LTD (GB) | 2008-12-17 | — | — | EP | claimed |