Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12875978 | 0.73 | HRH2 (0.36) | — | |
| SCHEMBL12888835 | 0.72 | JAK3 (0.51) | JAK2JAK1JAK3 | |
| SCHEMBL4761600 | 0.72 | JAK2 (0.44) | JAK2JAK1JAK3 | |
| SCHEMBL4762436 | 0.72 | JAK2 (0.44) | JAK2JAK1JAK3 | |
| SCHEMBL4762760 | 0.72 | JAK2 (0.31) | JAK2JAK1JAK3 | |
| SCHEMBL12887985 | 0.70 | JAK1 (0.62) | JAK2JAK1JAK3 | |
| SCHEMBL12861459 | 0.70 | — | — | |
| SCHEMBL12876670 | 0.69 | JAK1 (0.73) | JAK2JAK1JAK3 | |
| SCHEMBL12888836 | 0.69 | JAK1 (0.73) | JAK2JAK1JAK3 | |
| SCHEMBL1155116 | 0.69 | JAK1 (0.73) | JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966200-A1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | Astellas Pharma Inc. (JP) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007077949-A1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-07-12 | — | — | WO | disclosed |