Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alogliptin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 20/20 | 0.85 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.85 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alogliptin SCHEMBL174188 | 0.92 | DPP4 (1.00) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL121028 | 0.92 | DPP4 (1.00) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL17036596 | 0.92 | DPP4 (1.00) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL29352995 | 0.92 | DPP4 (1.00) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL475872 | 0.91 | DPP4 (0.98) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL17781892 | 0.91 | DPP4 (0.98) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL476232 | 0.91 | DPP4 (0.86) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL16246767 | 0.91 | DPP4 (0.86) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL30216225 | 0.91 | DPP4 (0.86) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL476231 | 0.91 | DPP4 (0.86) | DPP4OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2410855-B1 | PROCESS FOR THE PREPARATION OF ALOGLIPTIN | MAPI PHARMA LTD (IL) | 2016-06-01 | — | — | EP | disclosed |
| EP-2410855-A1 | PROCESS FOR THE PREPARATION OF ALOGLIPTIN | Mapi Pharma Limited (IL) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109468-A1 | PROCESS FOR THE PREPARATION OF ALOGLIPTIN | MAPI PHARMA HK LIMITED (CN) | 2010-09-30 | — | — | WO | disclosed |