Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.71 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762950 | 1.00 | BRAF (0.71) | BRAFROCK2MAPK14EIF2AK3CDK5 | |
| SCHEMBL4762938 | 1.00 | BRAF (0.71) | BRAFROCK2MAPK14EIF2AK3CDK5 | |
| SCHEMBL4761978 | 0.90 | BRAF (0.66) | BRAFROCK2MAPK14EIF2AK3 | |
| SCHEMBL4761970 | 0.90 | BRAF (0.66) | BRAFROCK2MAPK14EIF2AK3 | |
| SCHEMBL4764465 | 0.90 | BRAF (0.66) | BRAFROCK2MAPK14EIF2AK3 | |
| SCHEMBL4761962 | 0.90 | BRAF (0.66) | BRAFROCK2MAPK14EIF2AK3 | |
| SCHEMBL4761966 | 0.90 | BRAF (0.66) | BRAFROCK2MAPK14EIF2AK3 | |
| SCHEMBL14566685 | 0.89 | BRAF (0.56) | BRAFROCK2MAPK14EIF2AK3CDK5 | |
| SCHEMBL5623194 | 0.88 | BRAF (0.56) | BRAFROCK2MAPK14EIF2AK3CDK5 | |
| SCHEMBL5623192 | 0.88 | BRAF (0.56) | BRAFROCK2MAPK14EIF2AK3CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934228-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007027855-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| US-20070049603-A1 | Raf inhibitor compounds and methods of use thereof | ARRAY BIOPHARMA INC. | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049603-A1 | Raf inhibitor compounds and methods of use thereof | BRAF, RAF1, ARAF | BRAF 1/4885ROCK2 483/4885MAPK14 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.