Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 6/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL476350 | 0.90 | CNR1 (0.46) | CNR1CNR2TP53MDM2KIT | |
| SCHEMBL476428 | 0.89 | CNR1 (0.44) | CNR1CNR2HTR1ATP53MDM2 | |
| SCHEMBL6014240 | 0.88 | CNR1 (0.45) | CNR1CNR2TP53MDM2KIT | |
| SCHEMBL476384 | 0.88 | CNR1 (0.45) | CNR1CNR2TP53MDM2KIT | |
| SCHEMBL476263 | 0.88 | CNR1 (0.44) | CNR1CNR2HTR1ATP53MDM2 | |
| SCHEMBL2681558 | 0.88 | CNR1 (0.42) | CNR1CNR2HTR1ATP53MDM2 | |
| SCHEMBL2683112 | 0.88 | CNR1 (0.44) | CNR1CNR2TP53MDM2KIT | |
| SCHEMBL2682017 | 0.88 | CNR1 (0.42) | CNR1CNR2HTR1ATP53MDM2 | |
| SCHEMBL476270 | 0.85 | CNR1 (0.44) | CNR1CNR2TP53MDM2F10 | |
| SCHEMBL2682890 | 0.84 | CNR1 (0.40) | CNR1CNR2TP53MDM2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411383-B1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-10-22 | — | — | EP | claimed |
| EP-2411383-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-01 | — | — | EP | claimed |
| WO-2010109150-A1 | DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | claimed |