Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1855360 | 0.80 | CHRM2 (0.46) | MEN1KMT2AOPRD1SLC6A4SLC6A2 | |
| SCHEMBL7447748 | 0.78 | MEN1 (0.67) | MEN1KMT2AOPRD1SLC6A4SLC6A2 | |
| SCHEMBL4307025 | 0.77 | SLC6A4 (0.43) | MEN1KMT2ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2173657 | 0.76 | SLC6A4 (0.46) | MEN1KMT2ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL10385675 | 0.73 | MEN1 (0.66) | MEN1KMT2AOPRD1SLC6A4SLC6A2 | |
| SCHEMBL4764075 | 0.70 | MEN1 (0.43) | MEN1KMT2AOPRD1SLC6A4SLC6A2 | |
| SCHEMBL28000463 | 0.70 | SLC18A3 (0.35) | MEN1KMT2AOPRD1SLC6A4SLC6A2 | |
| SCHEMBL4285950 | 0.70 | SLC6A4 (0.43) | MEN1KMT2AOPRD1SLC6A4SLC6A2 | |
| SCHEMBL4285944 | 0.70 | SLC6A4 (0.35) | MEN1KMT2AOPRD1SLC6A4SLC6A2 | |
| SCHEMBL827528 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904498-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007004749-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | WO | disclosed |