Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.41 |
| ▸ | F2R | P25116 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 2/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14415577 | 0.97 | C5AR1 (0.52) | C5AR1HSP90AA1HSP90AB1F2RSMN1; SMN2 | |
| SCHEMBL5134563 | 0.92 | C5AR1 (0.60) | C5AR1HSP90AA1HSP90AB1F2RSMN1; SMN2 | |
| SCHEMBL5137863 | 0.91 | C5AR1 (0.45) | C5AR1HSP90AA1HSP90AB1F2RSMN1; SMN2 | |
| SCHEMBL1912763 | 0.90 | C5AR1 (0.58) | C5AR1HSP90AA1HSP90AB1F2RSMN1; SMN2 | |
| SCHEMBL5134627 | 0.87 | C5AR1 (0.55) | C5AR1HSP90AA1HSP90AB1F2RSMN1; SMN2 | |
| SCHEMBL4766728 | 0.83 | C5AR1 (0.51) | C5AR1HSP90AA1HSP90AB1F2RSMN1; SMN2 | |
| SCHEMBL5136213 | 0.82 | C5AR1 (0.50) | C5AR1HSP90AA1HSP90AB1F2RSMN1; SMN2 | |
| SCHEMBL5135964 | 0.82 | C5AR1 (0.47) | C5AR1HSP90AA1HSP90AB1F2RSMN1; SMN2 | |
| SCHEMBL650881 | 0.81 | C5AR1 (0.58) | C5AR1HSP90AA1HSP90AB1F2RSMN1; SMN2 | |
| SCHEMBL5147409 | 0.81 | C5AR1 (0.54) | C5AR1HSP90AA1HSP90AB1F2RSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322309-B1 | HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS | NEUROGEN CORP (US) | 2008-08-13 | — | — | EP | claimed |
| US-6723743-B1 | TREATING PATIENT SUFFERING FROM RHEUMATOID ARTHRITIS, PSORIASIS, BRONCHIAL ASTHMA, ALZHEIMER'S DISEASE, MYOCARDIAL INFARCTION OR ATHEROSCLEROSIS | NEUROGEN CORPORATION | 2004-04-20 | — | — | US | claimed |
| EP-1322309-B1 | HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS | NEUROGEN CORP (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2008011990-A2 | SYNERGISTIC INSECTICIDAL MIXTURES | BAYER CROPSCIENCE AG (DE) | 2008-01-31 | — | — | WO | disclosed |
| US-7271270-B2 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271270-B2 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271270-B2 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| US-20070027158-A1 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION | 2007-02-01 | — | — | US | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-1478644-A1 | SUBSTITUTED 4-PYRAZOLYL PYRAZOLINES USED FOR PEST CONTROL | Bayer CropScience AG (DE) | 2004-11-24 | — | — | EP | disclosed |
| US-6723743-B1 | TREATING PATIENT SUFFERING FROM RHEUMATOID ARTHRITIS, PSORIASIS, BRONCHIAL ASTHMA, ALZHEIMER'S DISEASE, MYOCARDIAL INFARCTION OR ATHEROSCLEROSIS | NEUROGEN CORPORATION | 2004-04-20 | — | — | US | disclosed |
| EP-1392695-A2 | TRIAZOLOPYRIMIDINES | Bayer CropScience AG (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |
| WO-2003070724-A1 | SUBSTITUTED 4-PYRAZOLYL PYRAZOLINES USED FOR PEST CONTROL | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2003-08-28 | — | — | WO | disclosed |
| EP-1311496-A1 | HETEROCYCLIC FLUOROALKENYL THIOETHERS AND THE USE THEREOF AS PESTICIDES (III) | Bayer CropScience AG (DE) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002088127-A2 | TRIAZOLOPYRIMIDINES | BAYER CROPSCIENCE AG (DE) | 2002-11-07 | — | — | WO | disclosed |
| WO-2002006257-A1 | HETEROCYCLIC FLUOROALKENYL THIOETHERS AND THE USE THEREOF AS PESTICIDES (III) | BAYER CROPSCIENCE AG (DE) | 2002-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027158-A1 | High affinity small molecule C5a receptor modulators | C3AR1, C5AR1, C5AR2 | C5AR1 2/4885HSP90AA1 4793/4885HSP90AB1 4825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.