Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764943 | 0.92 | PARP1 (0.59) | PARP1 | |
| SCHEMBL4761891 | 0.90 | PARP1 (0.58) | PARP1 | |
| SCHEMBL4768326 | 0.86 | PARP1 (0.51) | PARP1 | |
| SCHEMBL4762622 | 0.86 | PARP1 (0.59) | PARP1 | |
| SCHEMBL4764969 | 0.86 | PARP1 (0.59) | PARP1 | |
| SCHEMBL4769422 | 0.86 | PARP1 (0.59) | PARP1 | |
| SCHEMBL4768295 | 0.83 | PARP1 (0.57) | PARP1 | |
| SCHEMBL1422149 | 0.82 | PARP1 (0.50) | PARP1 | |
| SCHEMBL2264160 | 0.82 | PARP1 (0.59) | PARP1 | |
| SCHEMBL2265824 | 0.81 | PARP1 (0.74) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007733-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007113596-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-10-11 | — | — | WO | disclosed |