Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 15/20 | 0.45 |
| ▸ | CCND1 | P24385 | 12/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 11/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3677074 | 1.00 | CDK2 (0.45) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL3674104 | 1.00 | CDK2 (0.45) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL3670797 | 0.96 | CDK2 (0.47) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL3677941 | 0.94 | MAPK14 (0.48) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL3674729 | 0.94 | MAPK14 (0.48) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL3673605 | 0.94 | CCNE1 (0.49) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL3669287 | 0.94 | CCNE1 (0.49) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL4722727 | 0.94 | CCNE1 (0.49) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL3670875 | 0.93 | CCNE1 (0.47) | CDK2CCNE1CCND1CDK6CDK4 | |
| SCHEMBL3671028 | 0.93 | CCNE1 (0.47) | CDK2CCNE1CCND1CDK6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948167-A1 | COMPOSITIONS OF PHOSPHODIESTERASE TYPE IV INHIBITORS | RANBAXY LABORATORIES, LTD. (IN) | 2008-07-30 | — | — | EP | disclosed |
| EP-1931667-A1 | PYRIDO-PYRIDIMIDINE DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | Ranbaxy Laboratories Limited (IN) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007045980-A1 | COMPOSITIONS OF PHOSPHODIESTERASE TYPE IV INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007036791-A1 | PYRIDO-PYRIDIMIDINE DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | RANBAXY LABORATORIES LIMITED (US) | 2007-04-05 | — | — | WO | disclosed |