Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 18/20 | 0.59 |
| ▸ | HTR2C | P28335 | 17/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4660666 | 0.89 | HTR2A (0.72) | HTR2AHTR2CKMT2A | |
| SCHEMBL4661931 | 0.88 | HTR2A (0.59) | HTR2AHTR2CNPC1RAB9A | |
| SCHEMBL14397337 | 0.86 | HTR2A (0.52) | HTR2AHTR2C | |
| SCHEMBL4661836 | 0.83 | HTR2A (0.58) | HTR2AHTR2C | |
| SCHEMBL4792703 | 0.83 | HTR2A (0.59) | HTR2AHTR2C | |
| SCHEMBL4827321 | 0.82 | HTR2A (0.76) | HTR2AHTR2C | |
| SCHEMBL4660576 | 0.79 | HTR2A (0.60) | HTR2AHTR2CNPC1RAB9A | |
| SCHEMBL29574208 | 0.76 | HTR2A (0.73) | HTR2AHTR2C | |
| SCHEMBL5057446 | 0.76 | HTR2A (0.73) | HTR2AHTR2C | |
| SCHEMBL1165808 | 0.75 | HTR2A (1.00) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004627-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | claimed |
| WO-2007120600-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | claimed |
| EP-2004627-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120600-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |