Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PEPD | P12955 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18532463 | 1.00 | PEPD (0.42) | PEPDMEN1BLMKMT2AALDH1A1 | |
| SCHEMBL195046 | 1.00 | PEPD (0.42) | PEPDMEN1BLMKMT2AALDH1A1 | |
| SCHEMBL7734513 | 1.00 | PEPD (0.42) | PEPDMEN1BLMKMT2AALDH1A1 | |
| SCHEMBL7768150 | 0.98 | PEPD (0.41) | PEPDMEN1BLMKMT2AALDH1A1 | |
| SCHEMBL7598028 | 0.98 | PEPD (0.41) | PEPDMEN1BLMKMT2AALDH1A1 | |
| SCHEMBL9419364 | 0.98 | MEN1 (0.42) | PEPDMEN1BLMKMT2AALDH1A1 | |
| SCHEMBL7184111 | 0.98 | PEPD (0.41) | PEPDMEN1BLMKMT2AALDH1A1 | |
| SCHEMBL55536 | 0.98 | PEPD (0.41) | PEPDMEN1BLMKMT2AALDH1A1 | |
| SCHEMBL27481350 | 0.98 | PEPD (0.41) | PEPDMEN1BLMKMT2AALDH1A1 | |
| SCHEMBL8079733 | 0.98 | PEPD (0.41) | PEPDMEN1BLMKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699553-A1 | SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals, LLC (US) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012145569-A1 | SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2012-10-26 | — | — | WO | disclosed |
| EP-1505963-A4 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2008-12-24 | — | — | EP | disclosed |
| EP-1505963-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003099274-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-12-04 | — | — | WO | disclosed |