Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.62 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.62 |
| ▸ | HSP90B1 | P14625 | 4/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL487620 | 0.81 | HSP90AA1 (0.72) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL487588 | 0.81 | HSP90AA1 (0.72) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL487987 | 0.80 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL2948707 | 0.80 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1HSP90B1HDAC8 | |
| SCHEMBL487667 | 0.77 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL10256000 | 0.76 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1HSP90B1HDAC8 | |
| SCHEMBL15000795 | 0.76 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL10256275 | 0.76 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL488032 | 0.75 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1HSP90B1HDAC8 | |
| SCHEMBL2948708 | 0.75 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1HSP90B1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883402-A2 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 | Astex Therapeutics Limited (GB) | 2008-02-06 | — | — | EP | disclosed |
| WO-2006109075-A2 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 | ASTEX THERAPEUTICS LIMITED (GB) | 2006-10-19 | — | — | WO | disclosed |