Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | YES1 | P07947 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.54 |
| ▸ | WEE1 | P30291 | 1/20 | 0.54 |
| ▸ | ABL2 | P42684 | 1/20 | 0.54 |
| ▸ | NEK3 | P51956 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4764268 | 0.99 | KDR (0.54) | KDRERBB2EGFRSTK10MAP4K4 | |
| SCHEMBL4774356 | 0.89 | CSF1R (0.65) | KDRERBB2EGFRSTK10MAP4K4 | |
| Hydrochloric Acid SCHEMBL4765807 | 0.88 | CSF1R (0.64) | KDRERBB2EGFRSTK10MAP4K4 | |
| SCHEMBL4764690 | 0.87 | AXL (0.56) | KDRERBB2EGFRSTK10MAP4K4 | |
| SCHEMBL4764771 | 0.86 | EGFR (0.59) | KDRERBB2EGFRSTK10MAP4K4 | |
| SCHEMBL4774926 | 0.85 | TTBK1 (0.50) | KDRERBB2EGFRABL1PDGFRB | |
| SCHEMBL4768916 | 0.84 | KDR (0.51) | KDRERBB2EGFRSTK10MAP4K4 | |
| SCHEMBL4766925 | 0.84 | KDR (0.51) | KDRERBB2EGFRSTK10MAP4K4 | |
| SCHEMBL4767157 | 0.83 | AXL (0.52) | KDRERBB2EGFRSTK10MAP4K4 | |
| SCHEMBL4067576 | 0.83 | KDR (0.60) | KDRERBB2EGFRSTK10MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416935-B1 | 4-AMINO-6-PHENYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-03-12 | — | — | EP | claimed |