Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.59 |
| ▸ | TEK | Q02763 | 6/20 | 0.59 |
| ▸ | FLT1 | P17948 | 3/20 | 0.59 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767226 | 1.00 | KDR (0.59) | KDRTEKFLT1NSD3MAPK14 | |
| SCHEMBL4774512 | 0.83 | TEK (0.67) | KDRTEKFLT1NSD3MAPK14 | |
| SCHEMBL4774516 | 0.83 | TEK (0.67) | KDRTEKFLT1NSD3MAPK14 | |
| SCHEMBL4764875 | 0.74 | KDR (0.52) | KDRTEKFLT1NSD3NPC1 | |
| SCHEMBL4774487 | 0.74 | TEK (0.77) | KDRTEKFLT1NSD3 | |
| SCHEMBL4771725 | 0.74 | TEK (1.00) | KDRTEKFLT1MAPTKDM4E | |
| SCHEMBL4771720 | 0.74 | TEK (1.00) | KDRTEKFLT1MAPTKDM4E | |
| SCHEMBL4774491 | 0.74 | TEK (0.77) | KDRTEKFLT1NSD3 | |
| SCHEMBL4584865 | 0.73 | NSD3 (1.00) | KDRTEKFLT1NSD3MAPK14 | |
| SCHEMBL27619837 | 0.72 | TEK (0.70) | KDRTEKFLT1NSD3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575963-B1 | ANTI-ANGIOGENETIC THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2008-05-07 | — | — | EP | disclosed |
| US-20060069109-A1 | Therapeutic agents | ASTRAZENECA AB (SE) | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069109-A1 | Therapeutic agents | TIE1, TEK, KDR | KDR 3/4885TEK 2/4885FLT1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.