SCHEMBL4767602

SCHEMBL4767602

O=C(NCCc1ccc(O)cc1)c1ccc(C(=O)C(F)(F)F)s1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 9/20 0.78
HDAC6 Q9UBN7 8/20 0.78
HDAC4 P56524 7/20 0.78
HDAC3 O15379 7/20 0.78
NPC1 O15118 4/20 0.53
RAB9A P51151 4/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
ALDH1A1 P00352 2/20 0.53
ESRRG P62508 2/20 0.49
MLYCD O95822 1/20 0.49
ESRRB O95718 1/20 0.49
CYP1A2 P05177 1/20 0.48
GAA P10253 1/20 0.48
CYP2D6 P10635 1/20 0.48
MAPT P10636 1/20 0.48
CYP2C19 P33261 1/20 0.48
GFER P55789 1/20 0.48
KDM4E B2RXH2 1/20 0.48
F13A1 P00488 1/20 0.48
MEN1 O00255 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4774806 0.88 HDAC1 (1.00) HDAC1HDAC6HDAC4HDAC3NPC1
SCHEMBL2204286 0.85 HDAC1 (0.78) HDAC1HDAC6HDAC4HDAC3NPC1
SCHEMBL2203343 0.83 HDAC1 (0.80) HDAC1HDAC6HDAC4HDAC3NPC1
SCHEMBL2228785 0.81 HDAC1 (0.73) HDAC1HDAC6HDAC4HDAC3NPC1
SCHEMBL4770571 0.76 HDAC1 (0.67) HDAC1HDAC6HDAC4HDAC3NPC1
SCHEMBL2201378 0.76 HDAC1 (0.68) HDAC1HDAC6HDAC4HDAC3NPC1
SCHEMBL2201108 0.75 HDAC6 (1.00) HDAC1HDAC6HDAC4HDAC3
SCHEMBL2203603 0.75 HDAC1 (0.77) HDAC1HDAC6HDAC4HDAC3NPC1
SCHEMBL4776598 0.75 MAPK1 (0.68) HDAC1HDAC6HDAC4HDAC3ALDH1A1
SCHEMBL6433557 0.75 KDM4E (0.61) NPC1RAB9ASMN1; SMN2ALDH1A1ESRRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1926721-A2 THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) 2008-06-04 EP disclosed
WO-2007029035-A2 THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) 2007-03-15 WO disclosed