Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.74 |
| ▸ | LMNA | P02545 | 6/20 | 0.74 |
| ▸ | NPC1 | O15118 | 6/20 | 0.74 |
| ▸ | RAB9A | P51151 | 5/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.74 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.74 |
| ▸ | RELA | Q04206 | 3/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768541 | 1.00 | MAPT (0.74) | MAPTLMNANPC1RAB9AKDM4E | |
| Trifluoroacetic Acid SCHEMBL4765419 | 0.94 | MAPT (0.66) | MAPTLMNANPC1RAB9AKDM4E | |
| Trifluoroacetic Acid SCHEMBL4765425 | 0.94 | MAPT (0.66) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL8201867 | 0.83 | MAPT (0.63) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL8210516 | 0.83 | MAPT (0.75) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL8205361 | 0.83 | MAPT (0.75) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL4773031 | 0.83 | TRPV1 (0.53) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL4773020 | 0.83 | TRPV1 (0.53) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL4767410 | 0.83 | MAPT (0.57) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL4767400 | 0.83 | MAPT (0.57) | MAPTLMNANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |