Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 20/20 | 0.58 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.53 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13236873 | 0.82 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL383167 | 0.80 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL1954088 | 0.77 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL382952 | 0.77 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL383970 | 0.77 | HSP90AA1 (0.78) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL25317452 | 0.77 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL30368762 | 0.77 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| Hydrochloric Acid SCHEMBL384003 | 0.76 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| Hydrochloric Acid SCHEMBL30829343 | 0.76 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 | |
| SCHEMBL382308 | 0.76 | HSP90AA1 (0.76) | HSP90AA1HSP90AB1HDAC8HDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877379-A1 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 | Astex Therapeutics Limited (GB) | 2008-01-16 | — | — | EP | claimed |
| WO-2006109085-A1 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 | ASTEX THERAPEUTICS LIMITED (GB) | 2006-10-19 | — | — | WO | claimed |
| EP-1877379-A1 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 | Astex Therapeutics Limited (GB) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006109085-A1 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 | ASTEX THERAPEUTICS LIMITED (GB) | 2006-10-19 | — | — | WO | disclosed |