Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 16/20 | 0.62 |
| ▸ | GRK2 | P25098 | 15/20 | 0.62 |
| ▸ | GRK5 | P34947 | 8/20 | 0.62 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.62 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.62 |
| ▸ | GRK1 | Q15835 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2567105 | 0.86 | GRK2 (0.72) | ROCK1GRK2GRK5RPS6KA1RPS6KB1 | |
| SCHEMBL2569285 | 0.86 | GRK2 (0.68) | ROCK1GRK2GRK5RPS6KA1RPS6KB1 | |
| SCHEMBL2566271 | 0.86 | GRK2 (0.68) | ROCK1GRK2GRK5RPS6KA1RPS6KB1 | |
| SCHEMBL2569710 | 0.84 | GRK2 (0.68) | ROCK1GRK2GRK5RPS6KA1RPS6KB1 | |
| SCHEMBL2568590 | 0.83 | GRK2 (0.75) | ROCK1GRK2GRK5RPS6KA1RPS6KB1 | |
| SCHEMBL2567107 | 0.83 | GRK2 (0.77) | ROCK1GRK2GRK5RPS6KA1RPS6KB1 | |
| SCHEMBL2569551 | 0.82 | GRK2 (0.81) | ROCK1GRK2GRK5RPS6KA1RPS6KB1 | |
| SCHEMBL2567122 | 0.81 | ROCK1 (0.61) | ROCK1GRK2GRK5RPS6KA1RPS6KB1 | |
| SCHEMBL2566585 | 0.80 | GRK2 (0.78) | ROCK1GRK2GRK5RPS6KA1RPS6KB1 | |
| SCHEMBL2565978 | 0.80 | GRK2 (0.71) | ROCK1GRK2GRK5RPS6KA1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633740-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-11-19 | — | — | EP | claimed |
| JP-2007516173-A | — | — | 2007-06-21 | — | — | JP | claimed |
| EP-1633740-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2006-03-15 | — | — | EP | claimed |
| WO-2004112719-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-29 | — | — | WO | claimed |