Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.75 |
| ▸ | CDK8 | P49336 | 2/20 | 0.75 |
| ▸ | CDK1 | P06493 | 1/20 | 0.75 |
| ▸ | SRC | P12931 | 7/20 | 0.71 |
| ▸ | ABL1 | P00519 | 7/20 | 0.70 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.70 |
| ▸ | KDR | P35968 | 3/20 | 0.70 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.70 |
| ▸ | HCK | P08631 | 2/20 | 0.70 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.70 |
| ▸ | BRAF | P15056 | 2/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.70 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.70 |
| ▸ | AXL | P30530 | 2/20 | 0.70 |
| ▸ | FLT3 | P36888 | 2/20 | 0.70 |
| ▸ | MERTK | Q12866 | 2/20 | 0.70 |
| ▸ | ABL2 | P42684 | 2/20 | 0.70 |
| ▸ | STK25 | O00506 | 1/20 | 0.70 |
| ▸ | CIT | O14578 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29827937 | 1.00 | CDK2 (0.75) | CDK2CDK8CDK1SRCABL1 | |
| SCHEMBL4762420 | 0.93 | SRC (0.81) | CDK2CDK8CDK1SRCABL1 | |
| SCHEMBL3177191 | 0.92 | SRC (0.68) | CDK2CDK8CDK1SRCABL1 | |
| SCHEMBL4936999 | 0.91 | SRC (0.68) | CDK2CDK8CDK1SRCABL1 | |
| SCHEMBL4937797 | 0.91 | SRC (0.72) | CDK2CDK8CDK1SRCABL1 | |
| SCHEMBL4941049 | 0.90 | SRC (0.66) | CDK2CDK8CDK1SRCABL1 | |
| SCHEMBL4792487 | 0.89 | SRC (0.88) | CDK2CDK8CDK1SRCABL1 | |
| SCHEMBL22528915 | 0.89 | SRC (0.76) | CDK2CDK8CDK1SRCABL1 | |
| SCHEMBL22528795 | 0.87 | SRC (0.72) | CDK2CDK8CDK1SRCABL1 | |
| SCHEMBL21939208 | 0.86 | AXL (0.76) | CDK2CDK8CDK1SRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511730-B1 | DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | NOVARTIS AG (CH) | 2008-12-10 | — | — | EP | claimed |
| CN-115108998-B | Compounds for resisting hepatitis B virus and application thereof | 重庆医科大学 | 2023-06-30 | — | — | CN | disclosed |
| CN-115108998-A | Compound for resisting hepatitis B virus and application thereof | 重庆医科大学 | 2022-09-27 | — | — | CN | disclosed |